An endometrial tissue-based predictive model for polycystic ovary syndrome constructed from immuno-metabolic dysregulation features mediated by ACO1.

Although CHPF and STOML1 did not reach statistical significance, their expression trends were consistent with those observed in the training set (Figure S3B), further validating ACO1 as a stable diagnostic marker across cohorts. qRT-PCR validation of candidate gene expression To experimentally validate the core candidate genes, qRT-PCR was performed on ovarian granulosa cell samples obtained from clinical PCOS and control patients.

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