4-phenylbutyric acid attenuates hepatic ER stress, pyroptosis, and NAFLD in adult rat offspring exposed to a high-fat, high-fructose diet during perinatal and adulthood.

Lipids Health Dis · 2026 · PMC13037004 · PMID 41736066

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did not reach statistical significanceno p-value reported

However, administration of 4-PBA in the HFF-HFF-4PBA group resulted in a reduction of ALT levels compared with the HFF-HFF and HFF-HFF-DMSO groups, although the difference did not reach statistical significance.

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