Temporal and gene-specific dynamics of codon usage evolution in SARS-CoV-2 genomes.

BMC Genomics · 2026 · PMC13037255 · PMID 41735839

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a clear trendno p-value reported

Although the fraction of these codons never exceeded the expected value calculated for human codon usage, the increase in this frequency suggests a clear trend for optimisation of the viral codon usage with respect to human codon preferences.

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