Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier function in adults with obesity: A randomized, double-blind, placebo-controlled trial.

Gut Microbes Rep · 2026 · PMC13037523 · PMID 41924306

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

0.1630

boldest claim

The sentences

trending toward significancep < 0.1so close (0.05 < p ≤ 0.1)

The GLP-1 concentration increased in the OEA group at week 6 and week 12, which was trending toward significance ( p < 0.1).

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did not reach statistical significancep = 0.163not close (p > 0.1)

While the time x treatment interaction did not reach statistical significance (F(1, 37.8) = 2.02, p = 0.163), within-group analysis demonstrated a significant increase in F. prausnitzii abundance in the OEA group (mean change: +1.31%, 95% CI: 0.186 to 2.431, p = 0.009; paired t −test: t(19) = 2.284, p = 0.034), whereas the placebo group showed no significant change (mean change: +0.35%, 95% CI: −0.422 to 1.127, p = 0.487; paired t −test: t(18) = 0.892, p = 0.384).

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