Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models.

Our analysis also revealed a trend toward increased DC infiltration into the lungs of mice receiving IN Mip3a/relMtb (median 0.7% of total cells) compared with IN Mip3a/esat6 (median 0.2%), although this did not reach statistical significance ( P = 0.096), probably due to the high inter-animal variability and small sample size ( Supplemental Figure 3 ).

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