Computational analysis of multi-omics data reveals CXCL10<sup>+</sup> DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma.

In patients who exhibited poor responses to immune checkpoint blockade, both CXCL10 + DCs and Tregs showed a trend toward increased abundance post-treatment, accompanied by reduced spatial distance between the two populations.

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Moreover, these two cell types showed a highly significant positive correlation across multiple datasets.

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