Barely Significant
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Treatment resistance factors associated with Talaporfin sodium photodynamic therapy for local control after chemoradiotherapy for esophageal cancer.

Esophagus · 2026 · PMC13038797 · PMID 41545814

2
hedged sentences
0.0010
closest p · 0.0× alpha
0.0600
boldest claim

The sentences

highly significantP < 0.001actually significant
3 b) were 64.6% and 37.1% for L-CR, whereas non-L-CR was 0% at both time points, with a highly significant difference ( P < 0.001).

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did not reach statistical significanceP = 0.060so close (0.05 < p ≤ 0.1)
Although the initial treatment modality did not reach statistical significance, the observed odds ratio (odds ratio 4.2, P = 0.060) suggests a potentially meaningful impact on local control; no statistically significant difference was detected, and the initial treatment may be of substantial importance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.