SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.

Importantly, correlation analysis showed a moderate yet highly significant positive association between those two genes, this being confined in AML patients harbouring complex karyotype lesions only (R 2 = 0.49, p = 0.017), while no correlation was evident for any of the other cytogenetic subgroups reported in this cohort (Fig. 5C ).

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13 High), and although both overall and event-free survival analysis did not reach statistical significance (p = 0.056 and 0.05), the same adverse trend for the High group was retained (Fig. 5D ), with no statistically significant associations emerging between SPINK2 levels and specific mutational patterns (Fig. 5E ).

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