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Two-Year Outcomes of Less Invasive Surfactant Administration Among Preterm Neonates: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open · 2026 · PMC13040402 · PMID 41915392

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Binary logistic regression modeling revealed that randomization group (LISA vs CPAP) was not associated with the composite outcome of death or moderate to severe NDI at 2 years of age (OR, 0.84 [95% CI, 0.37-1.92]); infant sex (OR, 0.62 [95% CI, 0.27-1.43]) and maternal level of education (OR, 0.91 [95% CI, 0.32-2.59]) failed to reach statistical significance.

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