Development of a progressive HIV-1-Like infection model in northern pig-tailed macaques using stHIV-1sv/G53D.

Emerg Microbes Infect · 2026 · PMC13040574 · PMID 41914615

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showed a trendno p-value reported

GM-CSF, IL-6, and IP-10 showed a trend of elevation at this time point, though with considerable inter-individual variability, collectively indicating early immune hyperactivation.

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a decreasing trendno p-value reported

It is noteworthy that in two animals (#16223 and #17209), both viral DNA and RNA in PBMCs demonstrated a decreasing trend from 177 to 198 dpi, indicating a potential decrease in the cell-associated viral reservoir during this late phase.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.