Could brain-derived neurotrophic factor, irisin, and peroxisome proliferator-activated receptor-gamma be a pathway in cognitive impairment in schizophrenia?

BMC Psychiatry · 2026 · PMC13040862 · PMID 41742091

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0080

boldest claim

The sentences

highly significantp < 0.001actually significant

In the fully adjusted ANCOVA model, the diagnostic group effect for BDNF remained highly significant after controlling for age, sex, education level, BMI and smoking status (F = 11804.71, p < 0.001, partial η2 = 0.989).

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nominally significantp = 0.008actually significant

PPARγ showed one nominally significant correlation with Stroop-2 ( r = 0.215, p = 0.008) that did not survive FDR correction (q = 0.24).

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