Relation of Serum α-Amylase Level With Glycated Hemoglobin and Trace Elements in Patients With Diabetes Mellitus.

39 Only the association between α-amylase and FBG in control subjects showed a positive trend during the correlation analysis.

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Highlights • Serum α-amylase activity shows a significant negative correlation with glycated hemoglobin ( HbA1c ) in patients with type 2 Diabetes, suggesting its potential as a complementary marker for long-term glycemic control • Copper (Cu) levels were significantly elevated in the diabetic cohort compared to healthy controls, implicating altered copper metabolism in the disease's pathophysiology • Zinc (Zn) levels exhibited a negative trend with HbA1c, supporting the link between poor glycemic control and zinc deficiency, which may impair insulin synthesis and secretion • The study reveals a distinct pattern of trace element dysregulation (Cu, Zn, Mg) in diabetes, differentiating their behavior from that in healthy individuals • The f

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