showed a trendp = 0.09
Stage IV disease was independently associated with worse survival (adjusted HR, 2.18; 95% CI, 1.20–3.95; p = 0.01), whereas RECIST PD showed a trend toward poorer survival (adjusted HR, 1.62; 95% CI, 0.92–2.84; p = 0.09) (Online Resource S4 ).