Synergistic effects of fecal microbiota transplantation and andrographolide on gut microbiota modulation in dextran sulfate sodium-induced colitis in mice.

In comparison with the DSS treatment, FMT treatment demonstrated a partial reversal of the altered abundances for these bacterial phyla, though this did not reach statistical significance.

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Moreover, the relative abundance of Marinifilaceae shows a highly significant negative correlation with the expression of genes involved in cell cycle signaling pathways, suggesting that TLR2 exacerbates DSS-induced intestinal injury through a Marinifilaceae-dependent attenuation of cell cycle signaling ( Shi et al., 2024 ).

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