Genetic pharmacoepidemiology of JAK inhibitors in chronic immune-mediated skin diseases: implications for precision therapy and medication safety.

Front Pharmacol · 2026 · PMC13044065 · PMID 41939841

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nominally significantno p-value reported

In FinnGen, the TYK2 and PE association was also nominally significant; however, the HEIDI test was significant (P < 0.05), indicating heterogeneity that is more consistent with LD-driven linkage than a single shared causal variant.

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