Lefamulin versus omadacycline for community acquired bacterial pneumonia: a systematic review and anchored indirect treatment comparison using moxifloxacin as the common comparator.

J Comp Eff Res · 2026 · PMC13044819 · PMID 41823576

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a numerical trendno p-value reported

LEF showed a numerical trend toward favoring in multiple subgroups, including the elderly, patients with comorbidities, and those infected with specific pathogens, particularly in the ECR analysis.

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did not reach statistical significanceno p-value reported

TEAEs leading to death A numerical difference in the rate of TEAEs leading to deaths was observed, with LEF showing a lower point estimate than OMA, but this difference did not reach statistical significance (RR: 0.67, 95% CI: 0.15–3.02) ( Figure 5 ).

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