Modulatory role of endogenous adrenaline in propofol-related nociceptive responses in rats.

In this group, repeated measures ANOVA revealed a highly significant and robust main effect of time on the outcome measure (F (3, 15) = 198.98, p < 0.001), with a very large effect size (partial η 2 = 0.975).

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When anesthesia duration was evaluated, the 7.5-min duration observed with the anesthetic dose of propofol was reduced in the PRAD-50 group, although this reduction did not reach statistical significance.

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