Lipid Acyl Chain-Driven α-Synuclein Fibril Polymorphisms and Neuronal Pathologies.

Although these differences did not reach statistical significance, conformationally distinct PFFs showed a trend toward differential levels of pS129 accumulation ( Figure B).

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In contrast, in the presence of Aged membranes ( Figure C), an overall trend toward faster fibril formation was observed with higher L/P ratios.

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