Differentiation also exhibited an impact on tumor recurrence, although it did not reach statistical significance ( p = 0.05, HR = 1.50, 95% CI = 0.99–2.26).
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Evaluation of factors associated with the risk stratification of survivorship for stage IV squamous cell carcinoma of the oral cavity: A 10-year retrospective study.
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The result of multivariable Cox model identified the following variables as potential independent risk factors of DFS: T4N23 (HR = 1.78, 95% CI = 0.90–3.51, borderline significant), perineural invasion (HR = 1.89, 95% CI = 1.17–3.05) and positive surgical margin (HR = 1.66, 95% CI = 1.00–2.78, borderline significant) (Table 3 ). 4.