Single-cell transcriptomic profiling of the splenic and peripheral immune landscape in rhesus macaques during CHIKV infection.

Although most compositional shifts did not reach statistical significance, neutrophil enrichment in the spleen was statistically significant ( Fig. 1 H). 2.2 Neutrophils migrate to the spleen following CHIKV infection H&E staining detected marked histological injury in the spleen, which was primarily characterized by bleeding and lymphocyte infiltration ( Supporting Information 1 : Fig.

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