Choline and DNA methylation: impact across metabolic, oncogenic and neurodevelopmental disorders.

Clin Epigenetics · 2026 · PMC13049747 · PMID 41761204

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showed a trendno p-value reported

In human placental tissue, global methylation diverged by sex, whereby male placentas from PAE pregnancies exhibited decreased global DNA methylation, and female placentas showed a trend toward increased methylation (absolute methylation changes not reported) [ 99 ].

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