Development and Validation of a Traditional Chinese Medicine Constitution-Based Risk Score for Advanced Colorectal Neoplasia in Asymptomatic Chinese Adults.

In the final multivariate model for ACN ( Table 2 ), independent predictors were identified as follows: age ≥60 years (OR=3.46, 95% CI 1.30–9.21), current smoking, which demonstrated a trend toward significance (OR=1.95, 95% CI 0.92–4.11), and a family history of CRC in first-degree relatives (OR=4.43, 95% CI 1.43–17.32, P=0.033).

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The scoring system for smoking history was allocated a value of 1 point, reflecting its significant association with the development of colorectal tumors, although its influence on advanced tumors did not reach statistical significance (refer to Table S4 ).

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