Angiotensin II type 1 receptor signaling promotes bladder cancer progression and its inhibition by Losartan.

Hypertens Res · 2026 · PMC13050642 · PMID 41549123

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did not reach statistical significanceno p-value reported

Although patients with strong AGTR1 expression tended to present with multiple tumors at initial diagnosis, this trend did not reach statistical significance.

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a decreasing trendno p-value reported

Consistent with its in vitro property, phosphorylation of ERK showed a decreasing trend in mice transplanted with AGTR1-overexpressing tumors and treated with LOS, compared with untreated controls.

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