Identification of CCND1 and IL7R as core JAK-STAT pathway genes promoting hepatitis B-related liver fibrosis.

Front Immunol · 2026 · PMC13050702 · PMID 41948344

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a positive trendno p-value reported

In contrast, the causal effect of CCND1 on liver fibrosis did not reach statistical significance, although a positive trend was observed.

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did not reach statistical significanceno p-value reported

Inverse-variance weighted (IVW) Mendelian Randomization (MR) analysis showed a positive causal association between CCND1 and liver fibrosis (OR = 0.62, 95% CI: 0.11–3.59), but this did not reach statistical significance.

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