Genes From Epithelial-Mesenchymal Transition Predict Overall Survival Effectively in Breast Cancer: A Novel Risk Model Based on Initial Step of Tumor Metastasis.

Stratified KM curves revealed that the risk score distinguished OS within the TNBC subgroup with borderline significance (log-rank test, P < .05), whereas no significant prognostic differentiation was observed in Luminal A/B or HER2-enriched subtypes (all P > .05, Supplemental Figure 1B ).

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Interestingly, while not reaching strict statistical significance, the high-risk group showed a trend toward enrichment in the “extracellular region part” pathway, suggesting a potential role for transmembrane proteins and extracellular matrix remodeling in this aggressive phenotype, though further validation is required.

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