Changes in brain function during negative emotion processing following cognitive-behavioural therapy in depressive disorders.

Keywords Cognitive–behavioural therapy depression functional magnetic resonance imaging emotion processing limbic system Association of activity changes with response (objective b) Even if the subsequent analysis of responders versus non-responders showed only a nominally significant response × time interaction within the hippocampus ( P FWE = 0.068), post hoc t -tests revealed that responders showed a decrease in bilateral hippocampal activity during negative emotion processing between t 0 and t 1 (left: P FWE = 0.020, η p 2 = 0.204, 95% CI [0.0269, 0.3999]; right: P FWE = 0.005, η p 2 = 0.260, 95% CI [0.0556, 0.4509]; Supplementary Table 2 ).

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