Higher Colonic Tissue Drug Concentrations of Subcutaneous Compared to Intravenous Administration of Infliximab Therapy in Patients With Inflammatory Bowel Disease.

In the IV IFX cohort, the serum‐to‐colonic tissue ratio was likewise lower in patients with mild and moderate endoscopic activity (1.9 and 2.1, respectively) than in those in endoscopic remission (3.2) or with severe endoscopic activity (5.1), although this difference did not reach statistical significance ( p = 0.06). 3.5 Discrepancies Between Serum and Colonic Tissue IFX Drug Levels in Clinically Active Disease Among the 14 patients with clinically active disease, there was a trend toward lower serum‐to‐colonic tissue IFX concentration ratios compared with patients in clinical remission ( p = 0.06 for both), a finding likely driven by lower serum IFX concentrations in clinically active patients ( p = 0.06).

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