Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes.

The comparison ATA + versus ACA + and ARA + subgroups was highly significant ( P = 9.06 × 10 −18 , P = 2.88 × 10 −9 ), emphasizing C4A impact in ATA + patients (Figure 1 ).

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Conversely, C4B showed a significant association in ACA + patients (OR = 1.20, P = 1.61 × 10 −6 ) and ARA + patients (OR = 1.26, P = 0.012) (Figure 1 ), but the comparison between ATA + and ACA + groups did not reach statistical significance (Figure 1 ).

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