Effectiveness of Herbal Medicine Compared to Antidepressants in Patients with Schizophrenia Spectrum Disorders Accompanied by Depression: a systematic review and meta-analysis.

Adverse event rates showed a nonsignificant trend favoring HM (RR 0.56, 95% CI [0.06, 5.26]; low-certainty evidence).

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The findings indicated no significant difference between the two interventions in improving depressive symptoms, response rates, or general psychiatric symptoms, with a possible trend toward fewer adverse events in the HM group.

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Regarding safety, our meta-analysis of adverse events, based on two studies reporting quantitative data (215 participants), showed a trend toward lower adverse event rates in the HM group (RR 0.56, 95% CI [0.06, 5.26]; low-certainty evidence).

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