Investigating Early Kinetics in Plasma ctDNA and Peripheral T-cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Squamous Cell Carcinoma.

In contrast, ctDNA changes were not associated with OS at any time point although a nonsignificant trend suggested that any decrease of ctDNA from day 8 onward was associated with better OS.

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There was a trend indicating higher ctDNA levels (MTM/mL) in patients with metastases, primary tumors from the hypopharynx and larynx, and those with PD as best response; however, these associations did not reach statistical significance ( Table 1 ).

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