Barely Significant
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Accelerated brain ageing in migraine: a multilevel MRI-based brain-age modelling study.

Brain Commun · 2026 · PMC13056717 · PMID 41958921

Europe PMCDOI
2
hedged sentences
0.0920
closest p · 1.8× alpha
0.0920
boldest claim

The sentences

did not reach statistical significanceP = 0.092so close (0.05 < p ≤ 0.1)
Then, we stratified our patients by MRI protocol and found that the group differences in the two protocols showed consistent trend in the same direction as the combined analysis, respectively, although they did not reach statistical significance [IR-FSPGR: migraine: 0.315 ± 6.845 years; control: −4.115 ± 6.424 years; mean difference = 4.43 years; 95% CI (−0.56, 7.17); P = 0.092; η p 2 = 0.069; BRAVO: migraine: 7.989 ± 8.528 years; control: 5.206 ± 6.457 years; mean difference = 2.78 years; 95% CI (−0.49, 5.06); P = 0.106; η p 2 = 0.020].

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borderline significanceno p-value reported
Fourth, the increase in global BAG in patients with migraine showed borderline significance, warranting cautious interpretation.

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