Comparative evaluation of two NGS-based assays for somatic hypermutation analysis of IGHV genes in chronic lymphocytic leukemia.

Blood Res · 2026 · PMC13057106 · PMID 41941055

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Although the Leader assay tended to yield fewer inconclusive results than the FR1 assay, this difference did not reach statistical significance (exact McNemar’s test, p = 0.07).

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