Barely Significant
← all excerpts

Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro-Inflammatory M1 Macrophage Polarization in Periodontitis.

Mediators Inflamm · 2026 · PMC13058726 · PMID 41948871

Europe PMCDOI
3
hedged sentences
0.0001
closest p · 0.0× alpha
0.0001
boldest claim

The sentences

did not reach statistical significancep < 0.0001actually significant
Meta‐Analysis of Butyric Acid Concentration in Patients With Periodontitis Meta‐analysis indicated an overall decreasing trend in butyrate levels in GCF or saliva from patients with periodontitis; however, the difference did not reach statistical significance (SMD = −1.58, 95% CI: −6.53 to 3.36) and heterogeneity was substantial ( I 2 = 90.9%, p < 0.0001; Figure 3 A).

also in 111,027 other papers

a decreasing trendno p-value reported
In summary, butyrate levels derived from the microbial metabolites in patients with periodontitis showed a decreasing trend in the overall analysis but did not reach statistical significance.

also in 47,180 other papers

did not achieve significanceno p-value reported
Overall, while the combined results did not achieve significance, there is a trend toward increased isovaleric acid levels in periodontitis patients.

also in 1,397 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.