Fn14 is an activity-dependent, Bmal1-regulated cytokine receptor that induces rod-like microglia and restricts neuronal activity in vivo.

Fn14-KO mice froze less frequently than WTs when re-exposed to the spatial context (although this trend did not reach statistical significance), and they exhibited significantly less freezing when re-exposed to the auditory tone while in a novel environment (45.8 vs. 66.9 s; Figure 2B ).

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