No effective treatments for extensive muscle loss currently exist, and, as such, the health burden of VML is cumulatively quite significant. 3 Recently explored treatment strategies for VML include implantation of various biomaterials to enhance muscle regeneration, including decellularized extracellular matrix (ECM) scaffolds, mesenchymal stem cell scaffolds and more. 4 While some of these materials have shown promising results, none have been successful at fully restoring baseline functionality.
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Electronic health record mining reveals effects of patient immune status on clinical outcomes of biomaterial implantation following skeletal muscle damage.
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