Moreover, we carried out interaction analyses of both PhenoAgeAcc and BloodAgeAcc with the analyzed covariates, testing the influence of two-terms interactions for those clocks and covariates showing at least a nominally significant association (p < 0.05) with a given outcome.
An interaction analysis of the aging clocks tested and covariates revealed two significant associations with incident cancer hospitalization risk: one for the PhenoAgeAcc-by-(upper secondary) education interaction, which showed a significant negative marginal association (0.975 [0.959-0.993]); and one for the PhenoAgeAcc-by-smoking interaction, which showed a marginally significant positive marginal association (1.020 [1.001-1.038]; Table S10a-f ).