Comparative study on changes in serum amino acid metabolic profiles in mice exposed to perfluorooctanoic acid and sodium ρ-perfluorous nonenoxybenzene sulfonate.

Sci Rep · 2026 · PMC13061997 · PMID 41946941

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0540

boldest claim

The sentences

highly significantP < 0.01actually significant

Regarding amino acid derivatives, 11 compounds showed highly significant differences ( P < 0.01) and 3 showed significant differences ( P < 0.05) among the three groups.

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near-significantP = 0.054so close (0.05 < p ≤ 0.1)

Notably, several essential amino acids showed trends close to statistical significance: isoleucine levels exhibited a near-significant upward trend ( P = 0.054); tryptophan ( P = 0.066), phenylalanine ( P = 0.068), and valine ( P = 0.065) also showed trends toward alteration across the three groups, suggesting potential disturbances in branched-chain amino acid and aromatic amino acid metabolism that warrant further investigation.

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