RT-qPCR analysis of fibroblasts from these sites revealed a trend toward increased sEH (EPHX2) mRNA expression in vestibular fibroblasts from LPV patients compared to control subjects, and to their own external vulvar fibroblasts, although this difference did not reach statistical significance ( Figure 1B ).
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Soluble epoxide hydrolase inhibition restores pro-resolving lipid mediators and reduces inflammation in localized provoked vulvodynia.
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