Meta-Analysis of CYP1A1 MspI and Ile462Val Polymorphisms in Cancer Susceptibility Among Different Ethnic Populations.

Environ Mol Mutagen · 2026 · PMC13063359 · PMID 41369042

Europe PMC DOI

hedged sentences

0.0260

closest p · 0.5× alpha

0.2035

boldest claim

The sentences

somewhat significantp = 0.0260actually significant

The Asian group showed a somewhat significant association (OR = 1.22; 95% CI [0.28; 5.25], p = 0.0260), exhibiting high heterogeneity ( I 2 = 79.8%).

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borderline significantp = 0.2035not close (p > 0.1)

AA), Egger's test was borderline significant ( t = 2.054, df = 7, p = 0.2035) but above the conventional significance threshold, and Begg's test was not significant ( z = 1.25, p = 0.2109).

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approaching significanceno p-value reported

Stratification analyses suggested a protective effect approaching significance within Caucasian (OR = 0.78, 95% CI: 0.59–1.03), no significant association in others (OR = 1.37, 95% CI: 0.76–2.49), and significantly increased risk in the Asian subgroup (OR = 2.11, 95% CI: 1.45–3.06).

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highly significantno p-value reported

However, this overall significance was primarily derived from the Brazilian ethnic group because of its highly significant association (PR = 2.46; 95% CI [0.00; 305699178.1]) with high heterogeneity ( I 2 = 91.3%).

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