Comparative safety of esketamine in procedural sedation and analgesia: a systematic review and network meta-analysis.

BMC Anesthesiol · 2026 · PMC13063517 · PMID 41826847

Europe PMC DOI

hedged sentence

0.0615

closest p · 1.2× alpha

0.0615

boldest claim

The sentences

did not reach statistical significancep = 0.0615so close (0.05 < p ≤ 0.1)

Bradycardia Fentanyl demonstrated the highest point estimate for the risk of bradycardia relative to esketamine (RR 8.06), although this association did not reach statistical significance (95% CI 0.90 to 71.89, p = 0.0615).

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