Defects in auxiliary fuel oxidation and mitochondrial pyruvate transport mark transition to overt heart failure in Tgαq*44 mice.

Protein groups related to structural reorganisation generally presented an upward trend, while those linked to cardiac energy substrate metabolism demonstrated rather a decreasing trend (Fig. 4 and Sup.

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There was no significant difference in glutamate uptake in 4-month-old Tgαq*44 but a clear trend towards increased cardiac uptake in 14-month-old Tgαq*44 mice was observed.

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