Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS.

BMC Med · 2026 · PMC13064175 · PMID 41776545

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a strong trendno p-value reported

At the symptomatic stage, a strong trend towards decreased Angptl3 mRNA in the liver (the most crucial source of ANGPTL-3) of SOD1 mice was detected, which may account for the reduced serum levels.

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borderline significanceno p-value reported

Reverification by ELISA showed similar trends but with smaller R and borderline significance between ANGPTL-4 and AgRP and NPY on one side and between ANGPTL-4 and MMP2 on the other side (Additional file 2: Fig.

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