Association of prophylactic mannitol administration with perihemorrhagic edema and long-term outcome in patients with intracerebral hemorrhage.

BMC Neurol · 2026 · PMC13064179 · PMID 41923209

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hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

showed a trendp = 0.052so close (0.05 < p ≤ 0.1)

The peak ICH volume still showed a trend towards larger volumes in patients treated with mannitol (see Tables 5 and 21 (IQR 10–60) mL vs. 39 (IQR 16–59) mL, p = 0.052).

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a slight trendno p-value reported

Time-dependent associations with PHE growth After excluding patients with HS treatment, linear regression analysis adjusted for peak ICH volume revealed a slight trend towards a negative association of mannitol administration with edema evolution (i.e. reduced PHE development) shortly after initiation of mannitol therapy (PHE development between days 2–3 and days 4–6: b=-2.62, 95% CI -6.423-1.183, p = 0.176; ANOVA: corr.

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