Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells.

Cell Commun Signal · 2026 · PMC13064355 · PMID 41814308

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Moreover, TNBC patients with low PKM expression showed a trend towards benefitting from radiotherapy not quite reaching significance, while there is no difference in response to radiotherapy in TNBC patients with a high expression of PKM (Fig. 2 H).

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