Reduced IL-10 production by FoxP3+IL-10+ Treg cells is partially compensated by complosome-associated induction of regulatory FoxP3-IL-10+ T cells in allergic eosinophilic asthma.

Clin Exp Immunol · 2026 · PMC13064513 · PMID 41875927

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Activated CD4 + T cells from AEA patients show decreased LAG-3 expression AEA patients exhibited a normal frequency of CD4 + IL-10 + T cells and showed a trend towards increased IL-10 production per cell following αCD3/αCD46/IL-2 costimulation despite a reduced percentage of CD4 + CD25 + CD127 low Tregs in peripheral blood and decreased CD4 + FoxP3 + T cell frequencies after in vitro stimulation ( Supplementary Figure S6a ).

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