SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation.

CNS Spectr · 2025 · PMC13064777 · PMID 40814263

Europe PMC DOI

hedged sentences

0.0420

closest p · 0.8× alpha

0.0720

boldest claim

The sentences

borderline significancep = 0.042actually significant

However, the results changed to borderline significance after adjusting for clinical covariates in the analysis (p = 0.042), and the genotype at rs27072 did not modulate the methylation levels.

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did not reach statistical significancep = 0.072so close (0.05 < p ≤ 0.1)

CpG-2 island also exhibited lower methylation levels in the AUD group (mean = 0.66 ± 0.09) relative to controls (mean = 0.70 ± 0.08), although this difference did not reach statistical significance (p = 0.072).

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