Notably, studies have shown that FBLN7 knockout ( FBLN7 -KO) mice were protected from renal tubular calcification and showed a trend of alleviating kidney fibrosis when fed a high-phosphate diet ( Tsunezumi et al., 2018 ).
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Fibulin-7 in progenitor cells promotes adipose tissue fibrosis and disrupts metabolic homeostasis in obesity.
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