High-salt diet aggravates allergic rhinitis through the NFAT5 signaling pathway.

Compared to the AR group, the expression of Occludin and E-cadherin in the jejunum of the HSD group were significantly decreased, while the expression of Zo-1 and Mucin 2 showed a decreasing trend (Fig. 3I, K–M ).

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Compared to the CON group, IL-4 levels in the nasal lavage fluid of the HSD group were significantly higher than those in the AR group, and IL-5, IL-13, TSLP, IFN gama and IL-17 showed a trend toward increase (Fig. 2I–N ).

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S6D–G ).Compared with the PND group, the SSD group exhibited an increasing trend in sneezing frequency, nose-scratching frequency, and symptom score, although these levels were lower than those in the PSD group (Fig. 7B–D ).

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