Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.

Sci Rep · 2026 · PMC13065838 · PMID 41775781

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nominally significantp-value < 0.05actually significant

Colocalisation We employed the Bayesian colocalisation method coloc 69 to assess whether the nominally significant (p-value < 0.05) MR effects observed for drug targets were indicative of causation or potentially confounded by linkage disequilibrium (LD) 70 .

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