Integrative multi-omics dissection identifies ACO2, KLF5, and IMP4 as central regulators of the mitochondrial-immune axis in ulcerative colitis.

Front Immunol · 2026 · PMC13066277 · PMID 41972123

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a decreasing trendno p-value reported

did not reach statistical significanceno p-value reported

IMP4 was significantly upregulated in GSE66407 , whereas it showed a decreasing trend in GSE179285 and GSE11223 , although the differences did not reach statistical significance ( Figure 4C ).

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